February 08, 2019 | News
Are you interested in doing a PhD on digital health, 3D printing and pharmaceutical technologies? Are you on for a 1st or 2:1 in pharmacy, pharmacology, chemical engineering or a related subject? UCL School of Pharmacy and FabRx are recruiting a PhD student for an exciting 4 year project, fully funded by the EPSRC.
Around the world, narrow therapeutic index (NTI) drugs are used to treat a wide range of conditions, including microbial infections, epilepsy and coagulation disorders. However, these NTI drugs require regular therapeutic drug monitoring (TDM) and dose titrations, involving processes which are highly invasive (requiring the frequent withdrawal of blood samples) and expensive, costing the NHS over £136 million annually. To reduce the burden on healthcare services and to improve patient outcomes, a new method of point-of-care monitoring and drug dosing is required. As such, this project aims to engineer a non-invasive platform for real-time monitoring and personalised dosing of NTI drugs using three-dimensional printing. The project will be split into two parts: Part 1) development of a portable device for the rapid evaluation of drug levels in non-invasive biological fluids (e.g. saliva or urine) for use at the point-of-care and; Part 2) Development of personalised 3D printed dosage forms containing therapeutic drug dosages based on the clinical feedback from the portable device developed in Part 1. Via the intersection of these two cutting edge technologies, the management of NTI drugs will in the future be revolutionised, reducing healthcare spends and improving treatment outcomes.
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